This section features articles and position papers published by the International Osteoporosis Foundation’s Committee of Scientific Advisors and Working Groups. These publications are arranged by content type, and an external link or pdf is provided.
Epidemiology / Burden
FRAX / Technical Reports
Health Economics/ Models
Quality of Life
Secondary Fracture Prevention / Coordinator Based Systems
Treatment / Management
Vitamin D / Calcium
International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine Position on bone marker standards in osteoporosis
S. Vasikaran, C.Cooper, R.Eastell, A.Griesmacher, H. A. Morris, T. Trenti, J. A. Kanis (2011) Published online, Clinical Chemistry and Laboratory Medicine 49: 1271–1274
Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards
S. Vasikaran, R. Eastell, O. Bruyère, A. J. Foldes and P. Garnero, et al. (2011)
Osteoporos Int. 22: 391-420
Osteoporosis in the European Union: Medical Management, Epidemiology and Economic Burden. Hernlund E, Svedbom A, Ivergard M, Compston J, et. al. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA).
Arch Osteoporos 2013 [in press]
EU review panel of the IOF. Osteoporosis in the European Union: A compendium of country-specific reports.
Svedbom A, Hernlund E, Ivergard M, et al. Arch Osteoporos 2013 [in press].
A systematic review of hip fracture incidence and probability of fracture worldwide
J. A. Kanis & A. Odén & E. V. McCloskey & H. Johansson & D. A. Wahl & C. Cooper & on behalf of the IOF Working Group on Epidemiology and Quality of Life (2012) Osteoporos Int
Secular trends in the incidence of hip and other osteoporotic fractures
Cooper C, Cole, ZA, Holroyd CR et al (2011) Osteoporos Int 22: 1277-1288
An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
O. Johnell & J. A. Kanis (2006) Osteoporos Int 17:1726–1733
Treatment of patients with postmenopausal osteoporosis is worthwhile.
The position of the International Osteoporosis Foundation
Delmas PD, Rizzoli R, Cooper C, Reginster Y (2005) Osteoporos Int 16: 1-5
Requirements for DXA for the Management of Osteoporosis in Europe (PDF, 317.1 KB)
Kanis JA, Johnell O (2005) Osteoporos Int 16: 229–238.
European Action towards Better Musculoskeletal Health: A Public Health Strategy to Reduce the Burden of Musculoskeletal Conditions (PDF, 606 KB)
From the European Bone and Joint Health Strategies Project (BJD, EULAR, EFORT and IOF, 2004).
Note: Extensive references to FRAX-related scientific articles are listed on
Interpretation and use of FRAX in clinical practice
J. A. Kanis, D. Hans, C. Cooper, S. Baim, J. P. Bilezikian, N. Binkley, J. A. Cauley, J. E. Compston, B. Dawson-Hughes and G. El-Hajj Fuleihan, et al. (2011)
Osteoporos Int 22: 2395-2411
Read the series of IOF-ISCD position papers resulting from the IOF-ISCD FRAX Initiative published in the Journal of Clinical Densitometry
Case finding for the management of osteoporosis with FRAX®—assessment and intervention thresholds for the UK.
J. A. Kanis, E. V. McCloskey, H. Johansson, O.Strom, F. Borgstrom, A. Oden and National Osteoporosis Guideline Group (2008) Osteoporos Int 19: 1395-1408
Assessment of osteoporosis at the primary health care level. Technical Report. (PDF, 4.07 MB)
World Health Organization Collaborating Centre for Metabolic Bone Diseases. University of Sheffield, UK. Kanis JA on behalf of the World Health Organization Scientific Group (2007).
Latitude, socioeconomic prosperity, mobile phones and hip fracture risk (PDF, 109.8 KB)
O. Johnell, F. Borgstrom, B. Jonsson , J. Kanis (2007) Osteoporos Int :18:333–337
Osteoporosis: Burden, health care provision and opportunities in the European Union
O. Ström, F. Borgström, J.A. Kanis,J. Compston, C. Cooper, E. V. McCloskey & B. Jönsson. A report prepared in collaboration with IOF and EFPIA (2011)
Archives of Osteoporosis 6: 59-155
Development and validation of a disease model for postmenopausal osteoporosis. (PDF, 514.5 KB)
A. Gauthier, J.A. Kanis, M. Martin, J. Compston, F. Borgström, C. Cooper, E. McCloskey, on behalf of the IOF Committee of Scientific Advisors. (2010) Osteoporos Int 22: 771-780
Cost-effectiveness of the treatment and prevention of osteoporosis - a review of the literature and a reference model. Position Paper (PDF, 411.3 KB)
Zethraeus N, Borgström F, Ström O, Kanis JA, Jönsson B (2007) Osteoporos Int 18:9–23
Validation of the IOF quality of life questionnaire for patients with wrist fractures (PDF, 198.5 KB)
P. Lips, K. Jameson, M. L. Bianchi, S. Goemaere, S. Boonen, J. Reeve, J. Stepan, O. Johnell, N. M. van Schoor, E. Dennison, J. A. Kanis, C. Cooper & Working Group for Quality of Life of the International Osteoporosis Foundation (2009) Osteoporos Int 21:61-70
Capture the Fracture: A Best Practice Framework and Global Campaign to Break the Fragility Fracture Cycle.
Akesson K, Marsh D, Mitchell P, et al. IOF Fracture Working Group. Osteoporos Int 2013: http://link.springer.com/article/10.1007/s00198-013-2348-z
Coordinator-based systems for secondary prevention in fragility fracture patients.
D. Marsh, K. Åkesson, D. E. Beaton, E. R. Bogoch, S. Boonen, M.-L. Brandi, A. R. McLellan, P. J. Mitchell, J. E. M. Sale, D. A. Wahl and the IOF CSA Fracture Working Group (2011)
Osteoporos Int 22: 2051-2065
Editorial – Breaking the fragility fracture cycle. C. Cooper, P. Mitchell, J. A. Kanis (2011) Osteoporos Int 22: 2049-2050
The gaps between patient and physician understanding of the emotional and physical impact of osteoporosis. (PDF, 278.1 KB)
R. Rizzoli, ML Brandi, K. Dreinhöfer, T. Thomas, D. A. Wahl and C. Cooper. (2010) Arch Osteoporos 5:145–153.
Multinational survey of osteoporotic fracture management (PDF, 476.2 KB)
Dreinhöfer KE, Anderson M, Féron JM et al (2005) Osteoporos Int 16: S44–S53
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
J. A. Kanis & E. V. McCloskey & H. Johansson & C. Cooper & R. Rizzoli & J.-Y. Reginster &
on behalf of the Scientific Advisory Board of the European Society for Clinical and Economic
Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the Committee of Scientific Advisors
of the International Osteoporosis Foundation (IOF)
Osteoporos Int DOI 10.1007/s00198-012-2074-y
Download slide kit here
Impact of nutrition on muscle mass, strength, and performance in older adults
A. Mithal & J.-P. Bonjour, S. Boonen, P. Burckhardt, H. Degens, G. El Hajj Fuleihan, R. Josse, P. Lips, J. Morales Torres, R. Rizzoli, N. Yoshimura, D. A. Wahl, C. Cooper, B. Dawson-Hughes for the IOF CSA Nutrition Working Group. Osteoporos Int DOI 10.1007/s00198-012-2236-y
Treatment failure in osteoporosis
A. Diez-Perez, J. D. Adachi, D. Agnusdei, J. P. Bilezikian, J. E. Compston, S. R. Cummings, R. Eastell, E. F. Eriksen, J. Gonzalez-Macias and U. A. Liberman, et al.
Osteoporos Int 2012, DOI: 10.1007/s00198-012-2093-8
Osteoporosis in young adults: pathophysiology, diagnosis and management.
Serge Ferrari, Maria Luisa Bianchi, John A. Eisman, Joseph Foldes, Silvano Adami, Denys A. Wahl, Jan J. Steppan, Marie-Christine de Vernejoul, Jean-Marc Kaufman for the IOF Committee of Scientific Advisors Working Group on Osteoporosis Pathophysiology
Osteoporosis International 2012, DOI: 10.1007/s00198-012-2030-x
A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis.
S. Lekawasam, J. D. Adachi, D. Agnusdei, et al. for the Joint IOF-ECTS GIO Guidelines Working Group. Osteoporos Int
An appendix to the 2012 IOF–ECTS guidelines for the management of glucocorticoid-induced osteoporosis.
S. Lekamwasam, J. D. Adachi, D. Agnusdei, et al. for the Joint IOF-ECTS GIO Guidelines Working Group. Archives of Osteoporosis, March 2012
Subtrochanteric fractures after long-term treatment with bisphosphonates (PDF, 319 KB):
A European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report
R. Rizzoli, K. Åkesson, M. Bouxsein, J. A. Kanis and N. Napoli, et al. (2010) Osteoporos Int 22: 373-390
The cost-effectiveness of the treatment of high risk women with osteoporosis, hypertension and hyperlipidaemia in Sweden (PDF, 183.4 KB)
N. Zethraeus & O. Ström & F. Borgström & J. A. Kanis & B. Jönsson (2008) Osteoporos Int 19:819–827
European guidance for the diagnosis and management of osteoporosis in postmenopausal women. *Note European guidance published in 2012
Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster, JY, Borgström F, Rizzoli R, on behalf of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (2008). Osteoporos Int (2008) 19: 388-428.
The Impact of Osteonecrosis of the Jaw on Osteoporosis Management (PDF, 103.4 KB)
Executive Summary of a European Society on Clinical and Economic Aspects of Osteoporosis and Foundation for Research on Osteoporosis and other Bone Diseases Working Group Meeting (2007)
Balloon kyphoplasty and vertebroplasty in the management of vertebral compression fractures
S. Boonen, D. A. Wahl, L. Nauroy, M. L. Brandi, M. L. Bouxsein, J. Goldhahn, E. M. Lewiecki, G. P. Lyritis, D. Marsh and K. Obrant, et al. (2011)
Osteoporos Int 22: 2915-2934
The prevalence of radiographic vertebral fractures in Latin American countries: the Latin American Vertebral Osteoporosis Study (LAVOS)
P. Clark, F. Cons-Molina, M. Deleze, S. Ragi, L. Haddock, J. R. Zanchetta, J. J. Jaller, L. Palermo, J. O. Talavera, et al. (2008) Osteoporos Int 20: 275-282
A global representation of vitamin D status in healthy populations
D. A. Wahl, C. Cooper, P. R. Ebeling, M. Eggersdorfer and J. Hilger, et al.
Archives of Osteoporosis, 28 August 2012
IOF response to study linking calcium supplements to increased risk of heart attacks
Response to study in June 2012 issue of the journal Heart
June 14, 2012
IOF position statement: vitamin D recommendations for older adults (PDF, 98.6 KB)
B. Dawson-Hughes, A. Mithal, J.-P. Bonjour, S. Boonen, P. Burckhardt, G. E.-H. Fuleihan, R. G. Josse, P. Lips, J. Morales-Torres, N. Yoshimura on behalf of the IOF CSA Nutrition Working Group and Endorsed by the Committee of Scientific Advisors. Dawson-Hughes et al. (2010) Osteoporos Int 21:1151-1154
Global vitamin D status and determinants of hypovitaminosis D (PDF, 274 KB)
A. Mithal, D. A. Wahl, J-P. Bonjour, P. Burckhardt and B. Dawson-Hughes, et al. on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group. (2009)
Osteoporos Int 20: 1821
Download regional reports on vitamin D status for Asia, Europe, Middle East & Africa, Latin America, North America and Oceania
IOF comment on The Women’s Health Initiative (WHI) calcium plus vitamin D supplementation (PDF, 18.3 KB)
trial IOF Committee of Scientific Advisors (2006).